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Wisdom of crowds or wisdom of the few? How to improve estimations of energy needs in clinical practice
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 30 August 2010
Peter J.M., Weijs , Greet A.A.M., Vansant
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Longitudinal analysis of macronutrients and minerals in human milk produced by mothers of preterm infants
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 30 August 2010
Jacqueline, Bauer , Joachim, Gerss
 Background & aims: The primary objective of this study was to investigate the composition of breast milk of mothers with extremely preterm infants (<28 weeks) for their nutrient content over the first 8 weeks of lactation, and to compare premature to term milk. Methods: Breast milk from 102 mothers who had delivered preterm infants and from 10 mothers who had delivered term infants were collected longitudinally. Fat, protein, carbohydrate, minerals and energy content were estimated weekly in each participant. Milk samples were representative of complete 24-h cycles. Results: Carbohydrate, fat and energy concentrations were significantly higher in preterm than in term milk (p < 0.05). Protein content...
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Differences in fat content and fatty acid proportions among colostrum, transitional, and mature milk from women delivering very preterm, preterm, and term infants
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 25 August 2010
Carolina, Moltó-Puigmartà , Ana Isabel, Castellote , Xavier, Carbonell-Estrany , M. Carmen, López-Sabater
 Background & aims: Human milk composition changes according to gestational age and stage of lactation, but infants fed banked human milk often receive pooled milk. We studied the changes in fat content and fatty acid proportions throughout lactation in very preterm, preterm, and full term milk, and the differences among gestational age groups. Methods: Samples from women delivering before 30 (n = 10), between 30 and 37 (n = 10), and between 38 and 42 (n = 23) weeks of gestation were analyzed. Results: Fat content was higher in very preterm than in preterm and full term samples (p < 0.05). Medium-chain saturated fatty acids, alpha-linolenic acid, and rumenic acid proportions increased (p < 0.05)...
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ESPEN–Guidelines–Parenteral–Hepatology–Reply
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 24 August 2010
Mathias, Plauth , Tatjana, Schütz
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Body composition in childhood inflammatory bowel disease
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 21 August 2010
Anthony E., Wiskin , Stephen A., Wootton , Toby M., Hunt , Victoria R., Cornelius , Nadeem A., Afzal , ...
 Background & Aims: Little is known about the impact of disease and treatment on the pattern of growth in children with Inflammatory Bowel Disease (IBD). Significant deficits in height and weight in children with Crohn’s disease have been reported but changes in fat and fat free mass are less well defined. This study aims to describe the height, weight and body composition of a cohort of children with IBD. Methods: Height, weight, skinfold thicknesses and bioelectrical impedance analysis was performed. Disease activity was assessed with clinical scoring systems. Results: 55 children, median age 13.7 years (range 6.5–17.7) were studied. Median (25th, 75th percentile) Standard Deviation...
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Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia/cancer cachexia
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 19 August 2010
Calum, Gray , Thomas J., MacGillivray , Clare, Eeley , Nathan A., Stephens , Ian, Beggs , ...
 Background & aims: Sarcopenia and cachexia are characterized by infiltration of non-contractile tissue within muscle which influences area and volume measurements. We applied a statistical clustering (k-means) technique to magnetic resonance (MR) images of the quadriceps of young and elderly healthy women and women with cancer to objectively separate the contractile and non-contractile tissue compartments. Methods: MR scans of the thigh were obtained for 34 women (n = 16 young, (median) age 26y; n = 9 older, age 80y; n = 9 upper gastrointestinal cancer patients, age 65y). Segmented regions of consecutive axial images were used to calculate cross-sectional area and (gross) volume. The k-means unsupervised algorithm was subsequently...
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Fortification of breast milk in VLBW infants: Metabolic acidosis is linked to the composition of fortifiers and alters weight gain and bone mineralization
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 19 August 2010
Niels, Rochow , Frank, Jochum , Anke, Redlich , Zuzana, Korinekova , Kristina, Linnemann , ...
 Background & aims: Study objectives were to test (a) whether increased incidence of metabolic acidosis (MA) was caused by introduction of a new commercially available fortifier for breast milk, (b) if so, whether its modification would decrease the incidence of MA and (c) to analyze the impact of MA on growth. Methods: Double-blind randomized design. Healthy breast-fed infants (≤34 gestational weeks). Primary outcome measure was incidence of MA (BE < −6.0 mmol/L). Secondary outcome measures were growth, bone mineral content (BMC), vital signs, treatment with sodium hydrogen carbonate and Ca and laboratory parameters (pH, pCO2, HCO3ˉ, electrolytes). Results: Part 1 (comparison of standard (SF) and new fortifier (NF)):...
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Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia/cancer cachexia
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 19 August 2010
Calum, Gray , Thomas J., MacGillivray , Clare, Eeley , Nathan A., Stephens , Ian, Beggs , ...
 Background & aims: Sarcopenia and cachexia are characterized by infiltration of non-contractile tissue within muscle which influences area and volume measurements. We applied a statistical clustering (k-means) technique to magnetic resonance (MR) images of the quadriceps of young and elderly healthy women and women with cancer to objectively separate the contractile and non-contractile tissue compartments. Methods: MR scans of the thigh were obtained for 34 women (n = 16 young, (median) age 26y; n = 9 older, age 80y; n = 9 upper gastrointestinal cancer patients, age 65y). Segmented regions of consecutive axial images were used to calculate cross-sectional area and (gross) volume. The k-means unsupervised algorithm was subsequently...
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Fortification of breast milk in VLBW infants: Metabolic acidosis is linked to the composition of fortifiers and alters weight gain and bone mineralization
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 19 August 2010
Niels, Rochow , Frank, Jochum , Anke, Redlich , Zuzana, Korinekova , Kristina, Linnemann , ...
 Background & aims: Study objectives were to test (a) whether increased incidence of metabolic acidosis (MA) was caused by introduction of a new commercially available fortifier for breast milk, (b) if so, whether its modification would decrease the incidence of MA and (c) to analyze the impact of MA on growth. Methods: Double-blind randomized design. Healthy breast-fed infants (≤34 gestational weeks). Primary outcome measure was incidence of MA (BE < −6.0 mmol/L). Secondary outcome measures were growth, bone mineral content (BMC), vital signs, treatment with sodium hydrogen carbonate and Ca and laboratory parameters (pH, pCO2, HCO3ˉ, electrolytes). Results: Part 1 (comparison of standard (SF) and new fortifier (NF)):...
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Association of omega-3 fatty acids and homocysteine concentrations in pre-eclampsia☆
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 17 August 2010
Asmita, Kulkarni , Savita, Mehendale , Hemlata, Pisal , Anitha, Kilari , Kamini, Dangat , ...
 Background & aims: The present study examines the associations of folic acid, vitamin B12 and omega-3 fatty acids and increased homocysteine which are implicated in the pathology of pre-eclampsia. Methods: 49 Pre-eclamptic and 57 normotensive women were recruited at Bharati hospital, Pune, India. Plasma folate, vitamin B12, homocysteine and erythrocyte omega-3 and omega-6 fatty acids were analyzed. Results: Homocysteine concentrations were higher in pre-eclamptic than in normotensive women (14.28±7.31 vs. 11.03±4.38μmol/l, p<0.01) despite similar levels of folic acid and vitamin B12. In the pre-eclamptic group, plasma folate levels were positively associated with erythrocyte omega-6 fatty acids (p<0.05) while erythrocyte docosahexaenoic acid levels were negatively associated...
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Associations between nutritional status, weight loss, radiotherapy treatment toxicity and treatment outcomes in gastrointestinal cancer patients
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 17 August 2010
Amanda, Hill , Nicole, Kiss , Belinda, Hodgson , Timothy C., Crowe , Adam D., Walsh
 Background & aims: Patients with gastrointestinal cancers are susceptible to nutritional deterioration which may be compounded by radiotherapy treatment toxicities. This study aimed to determine whether nutritional status at radiotherapy commencement or changes in nutritional status throughout radiotherapy were associated with treatment toxicity and outcomes in gastrointestinal cancer patients. Methods: Seventy-three gastrointestinal cancer patients receiving curative radiotherapy underwent medical record audits assessing body weight, radiotherapy toxicity, unplanned treatment breaks or hospital admissions and completion of prescribed treatment/s. Nutritional status was assessed in a subset of patients (n = 11) using the Patient-Generated Subjective Global Assessment tool. Results: Seventy-five percent of patients lost weight throughout radiotherapy. Weight loss...
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The 2009 ESPEN Sir David Cuthbertson. Citrulline: A new major signaling molecule or just another player in the pharmaconutrition game?
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 16 August 2010
Luc, Cynober , Christophe, Moinard , Jean-Pascal, De Bandt
Citrulline (CIT) is synthesized from arginine (ARG) and glutamine in enterocytes and metabolized by the kidneys into arginine, which is available for peripheral tissues. Thus CIT, rather than ARG, could be a limiting amino acid (AA) in situations of intestinal failure. This was verified in a rat model of short bowel syndrome. The effects of CIT were further tested in renutrition of malnourished rats and in healthy volunteers fed a hypoproteic diet. CIT supplementation improved protein synthesis (PS) and ARG availability more than ARG itself, which is explained by the fact that CIT, unlike ARG, is very efficiently transported into...
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Parenteral branched-chain amino acids for hepatic encephalopathy. What is the grade of recommendation?
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 16 August 2010
Marcos F., Minicucci , Paula S., Azevedo , Sergio A.R., Paiva
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The prevalence of malnutrition and the evolution of nutritional status in patients with moderate to severe forms of Crohn’s disease treated with Infliximab
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 16 August 2010
Roxana, Vadan , Liliana Simona, Gheorghe , Alexandrina, Constantinescu , Cristian, Gheorghe
 Background & aims: Malnutrition is variably encountered in adult patients with Crohn’s disease. We evaluated the nutritional status at the beginning and during Infliximab treatment in patients with Crohn’s disease. Methods: Patients with moderate/severe flares of disease treated with Infliximab for induction and maintenance of remission were included in a prospective observational study. Body Mass Index and Nutritional Risk Index were calculated in each patient at 0, 6 weeks and than every 8 weeks for one year. Results: From 30 patients treated with Infliximab 59.3% had low BMI, 35.7% being undernourished. The severity of Crohn’s disease did not correlate with low BMI but did correlate...
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Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 13 August 2010
Magdalena, Makarewicz-Wujec , Malgorzata, Kozlowska-Wojciechowska
 Background & aims: Dietary quality probably may impact heart failure outcomes. The aim of the study was to determine the potential effects of nutrient intake on homocysteine, MCP-1 and GGT levels in patients with heart failure. Methods: The study group comprised 55 patients with diagnosed HF with coronary artery disease origin, below 65y, with NYHA class I/II. The patients had received standard treatment. The control comprised 55 patients with mild hyperlipidemia, not treated. Diet was evaluated on the basis of a dietary questionnaire and a 24-h dietary recall. The serum lipid profile, folic acid, homocysteine, GGT and MCP-1 were determined. Results: In the HF group...
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Complementarity of Subjective Global Assessment (SGA) and Nutritional Risk Screening 2002 (NRS 2002) for predicting poor clinical outcomes in hospitalized patients
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 12 August 2010
Mariana, Raslan , Maria Cristina, Gonzalez , Raquel Suzana M.M., Torrinhas , Graziela Rosa, Ravacci , Julio C.R., Pereira , ...
 Background & aims: We evaluated the ability of Nutritional Risk Screening 2002 (NRS 2002) and Subjective Global Assessment (SGA) to predict malnutrition related to poor clinical outcomes. Methods: We assessed 705 patients at a public university hospital within 48h of admission. Logistic regression and number needed to screen (NNS) were calculated to test the complementarity between the tools and their ability to predict very long length of hospital stay (VLLOS), complications, and death. Results: Of the patients screened, 27.9% were at nutritional risk (NRS+) and 38.9% were malnourished (SGA B or C). Compared to those patients not at nutritional risk, NRS+, SGA B or C...
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Aggregate prediction of resting energy expenditure may perform better than individual estimates
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 12 August 2010
Mario, Siervo , Jonathan, Wells
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N-3 polyunsaturated fatty acids early supplementation improves ultrasound indices of endothelial function, but not through NO inhibitors in patients with acute myocardial infarctionN-3 PUFA supplementation in acute myocardial infarction.
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 12 August 2010
Maciej, Haberka , Katarzyna, Mizia - Stec , Magdalena, Mizia , Joanna, Janowska , Klaudia, Gieszczyk , ...
 Background & aims: our aim was to evaluate early initiated one month n-3 polyunsaturated fatty acids (PUFA) supplementation effects on ultrasound indices of endothelial function and serum asymmetric dimethylarginine (ADMA) levels in patients with acute myocardial infarction (AMI). Methods: Forty patients with AMI and successful percutaneous coronary intervention (PCI) were recruited into the study and randomized to the study group (group P; n = 20; standard therapy + n-3 PUFA 1g daily) or the control group (group C; n = 20; standard therapy). Ultrasound indices of endothelial function: flow-mediated dilatation (FMD), nitroglycerin-mediated dilatation (NMD) and serum ADMA concentrations (ELISA) were obtained before and after one month (30 ± 1 days) therapy...
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Effects of dietary glutamine on adhesion molecule expression and oxidative stress in mice with streptozotocin-induced type 1 diabetes
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 11 August 2010
Pei-Hsuan, Tsai , Jun-Jen, Liu , Wan-Chun, Chiu , Man-Hui, Pai , Sung-Ling, Yeh
 Background & aims: Glutamine (Gln) is known to have immunomodulatory effects. Previous studies reported that Gln promotes insulin secretion in type 2 diabetes. However, the effects of Gln on insulin-deficient type 1 diabetes are not clear. This study investigated the effects of dietary Gln supplementation on adhesion molecule expression and oxidative damage in type 1 diabetic mice. Methods: There were 1 normal control (NC) group and 2 diabetic groups in this study. Mice in the NC group were fed a regular chow diet. One diabetic group (DM) was fed a common semipurified diet while the other diabetic group received a diet in which...
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The compliance of medical staff for the routine administration of iron in the 1st year to their children
Publication year: 2010
Source: Clinical Nutrition, In Press, Corrected Proof, Available online 5 August 2010
Gabi, Haran , Lisa, Rubin , Ron, Shaoul
 Background & aims: We aimed to study the personal compliance of physicians and nurses with recommendations for the administration of iron supplements for their own children and their compliance with the routine child and maternal health care surveillance recommended during the first year of life. Methods: Five hundred physicians and nurses from Haifa and Tel Aviv area working in hospitals and the community were asked to answer a self administered questionnaire. The questionnaire included questions assessing their compliance (using a 100 mm analogue visual scale) with iron and vitamin A + D supplementation, immunizations and routine examinations at the child and maternal health care center for...
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