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Methylenetetrahydrofolate reductase polymorphism: An independent risk determinant of coronary heart disease in an endogamous population from Delhi (India)☆
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 24 August 2010
Ekata, Sinha , Gagandeep Kaur, Walia , Rupak, Mukhopadhyay , Ratika, Samtani , Budh Prakash, Gupta , ...
 Background & Aims: Methylenetetrahydrofolate reductase catalyzes the conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the folate metabolic pathway. Of the numerous polymorphisms reported worldwide in this gene, C677T and A1298C are the most extensively studied with respect to various complex disorders. The present study attempts to understand the effect of these two polymorphisms on the causation of coronary heart disease in a Mendelian population of a specific geographical area in India. Methods: The study was carried out using 100 cases and 100 age, sex, geography and ethnicity matched controls. Blood samples were subjected to biochemical and molecular analysis. Medical histories and anthropometric measurements...
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Effects of nutritional replacement on somatic and bone tissue growth in young malnourished rats☆
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 21 August 2010
Karina, de Carvalho da Silva , Fabiana Soares, Bizarria , Rafael Justino, da Silva , Camilla Rodrigues, de Souza Silva , Rita, de Cássia da Silva Costa , ...
 Background & aims: To evaluate the effects of nutritional replacement on somatic and bone tissue growth in young malnourished rats. Methods: 30 rats, groups: Nourished (NG), Malnourished (MG), Replacement (RG). Malnutrition promoted by 8% casein and replacement by 17% casein. Body weight recorded daily. At 36 days of age, the animals were sacrificed. Analyses included: weight and length of the femur and tibia, number of proliferative and hypertrophic chondrocytes. Results: Lower body weight in MG and RG compared to NG. Between MG and RG, body weight greater in RG, from 32nd day. Length and weight of the femur and tibia lower in MG and RG...
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Measuring energy expenditure and body composition in children with neurological impairment and intellectual disability using the doubly labeled water method: Comparing urine and saliva sampling
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 19 August 2010
Rob, Rieken , Henk, Schierbeek , Johannes B., van Goudoever , Dick, Tibboel , Heleen M., Evenhuis , ...
 Background & Aims: Information is lacking on the comparability of the outcomes of the doubly labeled water method using urine and saliva samples in children with severe neurological impairment and intellectual disability (ID). Our aim is to compare outcomes and feasibility based on both sampling methods. Methods: Total energy expenditure (TEE) and total body water (TBW) were calculated using urine and saliva samples of thirteen children (aged 3–15 y). To correct for age and weight, TEE was expressed as a percentage of recommended daily allowance (%TEE of RDA) and TBW as a percentage of weight (%TBW). Agreement between methods was evaluated using Bland and...
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Measuring energy expenditure and body composition in children with neurological impairment and intellectual disability using the doubly labeled water method: Comparing urine and saliva sampling
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 19 August 2010
Rob, Rieken , Henk, Schierbeek , Johannes B., van Goudoever , Dick, Tibboel , Heleen M., Evenhuis , ...
 Background & Aims: Information is lacking on the comparability of the outcomes of the doubly labeled water method using urine and saliva samples in children with severe neurological impairment and intellectual disability (ID). Our aim is to compare outcomes and feasibility based on both sampling methods. Methods: Total energy expenditure (TEE) and total body water (TBW) were calculated using urine and saliva samples of thirteen children (aged 3–15 y). To correct for age and weight, TEE was expressed as a percentage of recommended daily allowance (%TEE of RDA) and TBW as a percentage of weight (%TBW). Agreement between methods was evaluated using Bland and...
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Concomitant apolipoprotein A-IV and citrulline plasma changes during short-term parenteral nutrition in surgical patients
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 17 August 2010
Carmen, Través , Elena, GarcÃa-Arumà , Joan, López-HellÃn , Juan Antonio, Baena-Fustegueras , M. Dolores, López-Tejero
 Background & Aim: Apolipoprotein A-IV (apo A-IV) and citrulline are non-invasive biomarkers that can be used to monitor nutritional and intestinal changes in patients receiving parenteral nutrition (PN). Yet, while the role of citrulline has been well established, further research is needed to understand apo A-IV’s utility. Methods: Twenty-eight patients who underwent gastrointestinal surgery by laparotomy, either a subtotal gastrectomy or a hemicolectomy, and were placed on short-term PN, were selected and assigned on a Parenteral-Oral (4-day PN and 4-day oral, 8 patients) or a Parenteral-Only (7-day PN, 20 patients) nutritional regime. They were delivered PN solutions (PN1 to PN4) containing varying amounts...
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Effect of red yeast rice on toxicity of oxidized cholesterol and oxidized fish oil in rats
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 2 August 2010
Yen-Hung, Yeh , Ya-Ting, Lee , Hung-Sheng, Hsieh , Deng-Fwu, Hwang
 Background & Aims: A study was undertaken to investigate the effect of red yeast rice on oxidized cholesterol and oxidized fish oil-induced toxicity in male Wistar rats. Methods: The rats were divided into five groups, 30 male Wistar rats were fed with diets supplemented with 1% red yeast rice, 2% oxidized cholesterol or 3% oxidized fish oil for 6 weeks. Results: Red yeast rice increase the levels of high-density lipoprotein cholesterol (HDL-C) in plasma, and glutathione (GSH) level in plasma, and decrease the activities of alkaline phosphatase (ALP), alanine transaminase (ALT) and aspartate transaminase (AST) in plasma, and the levels of low-density lipoprotein cholesterol (LDL-C),...
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The [1-13C]acetate recovery factor to correct tracer-derived dietary fat oxidation is lower in overweight insulin-resistant subjects
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 18 June 2010
Edwina, Antoun , Iman, Momken , Audrey, Bergouignan , Clément, Villars , Carine, Platat , ...
 Background&aims: An acetate recovery factor (ARF) is utilized to correct tracer-derived fat oxidation when 13C is used. We showed that when 13C labelled fatty acid are given orally, dietary fat oxidation can be accurately corrected by using an averaged dietary ARF (dARF) derived from 56 lean healthy subjects, instead of individual dARF. The extent to which this factor is valid in overweight insulin resistant subjects is unknown. Methods: [1-13C]dARF and [1-13C]fatty acid recoveries were assessed before and after physical activity/inactivity interventions in overweight insulin-resistant (n = 11) and lean subjects (n = 70) in five studies herein compiled. Results: Overweight dARF was lower compared to...
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The [1-13C]acetate recovery factor to correct tracer-derived dietary fat oxidation is lower in overweight insulin-resistant subjects
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 18 June 2010
Edwina, Antoun , Iman, Momken , Audrey, Bergouignan , Clément, Villars , Carine, Platat , ...
 Background&aims: An acetate recovery factor (ARF) is utilized to correct tracer-derived fat oxidation when 13C is used. We showed that when 13C labelled fatty acid are given orally, dietary fat oxidation can be accurately corrected by using an averaged dietary ARF (dARF) derived from 56 lean healthy subjects, instead of individual dARF. The extent to which this factor is valid in overweight insulin resistant subjects is unknown. Methods: [1-13C]dARF and [1-13C]fatty acid recoveries were assessed before and after physical activity/inactivity interventions in overweight insulin-resistant (n = 11) and lean subjects (n = 70) in five studies herein compiled. Results: Overweight dARF was lower compared to...
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The role of vitamin D deficiency in the pathogenesis of type 2 diabetes mellitus
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 11 June 2010
Tracy S., Moreira , Mazen J., Hamadeh
Physical inactivity, poor nutrition practices and obesity contribute significantly to the development of T2DM, however increasing evidence suggests that vitamin D deficiency may play a role in the pathogenesis of T2DM. T2DM manifests as a result of insulin resistance, increased hepatic glucose production and β-cell failure. Vitamin D deficiency increases insulin resistance and decreases insulin secretion in humans and animal models. Conversely, vitamin D supplementation restores insulin secretion and decreases insulin resistance and plasma glucose in humans and animal models. Vitamin D metabolites are thought to play a role in increasing insulin sensitivity and facilitating insulin exocytosis. Vitamin D has...
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The role of vitamin D deficiency in the pathogenesis of type 2 diabetes mellitus
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 11 June 2010
Tracy S., Moreira , Mazen J., Hamadeh
Physical inactivity, poor nutrition practices and obesity contribute significantly to the development of T2DM, however increasing evidence suggests that vitamin D deficiency may play a role in the pathogenesis of T2DM. T2DM manifests as a result of insulin resistance, increased hepatic glucose production and β-cell failure. Vitamin D deficiency increases insulin resistance and decreases insulin secretion in humans and animal models. Conversely, vitamin D supplementation restores insulin secretion and decreases insulin resistance and plasma glucose in humans and animal models. Vitamin D metabolites are thought to play a role in increasing insulin sensitivity and facilitating insulin exocytosis. Vitamin D has...
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The use of prophylactic percutaneous endoscopic gastrostomy and early enteral feeding in patients with advanced head and neck cancer-A prospective longitudinal study
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 23 May 2010
Ewa, Silander , Jan, Nyman , Mogens, Bove , Leif, Johansson , Sven, Larsson , ...
 Background&aims: This descriptive study aimed to explore the effect of early nutritional support and enteral feeding using percutaneous endoscopic gastrostomy (PEG) in preventing malnutrition in patients with locally advanced head-neck cancer. Method: Sixty-four patients received a prophylactic PEG before treatment. Weight, body mass index (BMI), body composition, fat free mass index (FFMI), dysphagia and use of tube feeding were followed during two years. Results: The patients started to use their PEGs on average 30 days after treatment start and used enteral feeding for 180 days. PEG was well tolerated with few side-effects. After one-year 89% had returned to almost normal diet. At the time of...
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A comparison of 25-hydroxyvitamin D serum levels in acute and long-stay psychiatric inpatients: A preliminary investigation
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 23 May 2010
Lisa J., Norelli , Andrew D., Coates , Beatrice M., Kovasznay
 Background and aims: Little is known about the vitamin D status of patients with severe psychiatric disorders, a potential contributing factor to elevated rates of morbidity and mortality. This descriptive study assessed serum 25-hydroxyvitamin D [25(OH)D] levels in hospital patients with schizophrenia-spectrum disorder, compared to a non-patient control group. Methods: Assessment of serum 25(OH)D levels in 20 acute care (≤60 days), 20 long-stay (≥6 months) adult public psychiatric hospital inpatients with schizophrenia-spectrum disorders, compared to 20 normal controls. Results: High rates of hypovitaminosis D were found in all three groups with no significant differences in levels between groups: mean±SD 25(OH)D levels acute care patients 19.1±9.8ng/ml,...
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The use of prophylactic percutaneous endoscopic gastrostomy and early enteral feeding in patients with advanced head and neck cancer-A prospective longitudinal study
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 23 May 2010
Ewa, Silander , Jan, Nyman , Mogens, Bove , Leif, Johansson , Sven, Larsson , ...
 Background&aims: This descriptive study aimed to explore the effect of early nutritional support and enteral feeding using percutaneous endoscopic gastrostomy (PEG) in preventing malnutrition in patients with locally advanced head-neck cancer. Method: Sixty-four patients received a prophylactic PEG before treatment. Weight, body mass index (BMI), body composition, fat free mass index (FFMI), dysphagia and use of tube feeding were followed during two years. Results: The patients started to use their PEGs on average 30 days after treatment start and used enteral feeding for 180 days. PEG was well tolerated with few side-effects. After one-year 89% had returned to almost normal diet. At the time of...
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A comparison of 25-hydroxyvitamin D serum levels in acute and long-stay psychiatric inpatients: A preliminary investigation
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 23 May 2010
Lisa J., Norelli , Andrew D., Coates , Beatrice M., Kovasznay
 Background and aims: Little is known about the vitamin D status of patients with severe psychiatric disorders, a potential contributing factor to elevated rates of morbidity and mortality. This descriptive study assessed serum 25-hydroxyvitamin D [25(OH)D] levels in hospital patients with schizophrenia-spectrum disorder, compared to a non-patient control group. Methods: Assessment of serum 25(OH)D levels in 20 acute care (≤60 days), 20 long-stay (≥6 months) adult public psychiatric hospital inpatients with schizophrenia-spectrum disorders, compared to 20 normal controls. Results: High rates of hypovitaminosis D were found in all three groups with no significant differences in levels between groups: mean±SD 25(OH)D levels acute care patients 19.1±9.8ng/ml,...
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Nutritional status and energy expenditure after a programme of nutrition education and combined aerobic/resistance training in obese women
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 18 May 2010
Camila M., de Melo , Julio, Tirapegui , Daniel, Cohen , Julio S., Marchini , Sandra M., Lima Ribeiro
 Background & aims: we investigated changes in markers of nutritional status and energy expenditure after a programme of nutrition education and combined aerobic/resistance training in obese women and distinguished these changes in association with the loss, or not, of body weight. Methods: Obese women (30–50 years) participated in a nutritional education and physical training programme for four months. Variables analysed: anthropometric measures, body composition (by DEXA) and some biochemical markers of nutritional status (leptin, IGF-I, pre-albumin, albumin, hemogram) and of risk of chronic diseases (blood glucose, total cholesterol, HDL, LDL, triacylglycerol). Results: Body mass changes were from −6.0 to +4.0 Kg. All women decreased waist...
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Israeli guidelines for the management of hypercholesterolemia in children and adolescents. Report of the pediatric association expert group
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 1 May 2010
Hofit, Cohen , Chen, Stein-Zamir , Orit, Hamiel , Yael, Lebenthal , Daniel, Schurr , ...
 Background & aims: Elevated plasma LDL-C levels hold an essential role in the pathogenesis of the atherosclerotic process, which in fact initiates in childhood and early adolescence. The detection and intervention of hyperlipidemia among that age group may disrupt or prevent the progression of the atherosclerosis. Guidelines for the diagnosis and treatment of hypercholesterolemia among children and adolescents were published only in the United States. The current guidelines aim at providing a thorough assessment of the current concepts in the diagnosis, screening and therapeutic options for hypercholesterolemia in the pediatric age group. Methods and results: Literature review of Pubmed (1968–November 1, 2009) and...
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Effects of a low threshold health promotion intervention on the BMI in pre-school children under consideration of parental participation
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 30 April 2010
Daniel, Klein , Daniela, De Toia , Sarah, Weber , Nicolas, Wessely , Benjamin, Koch , ...
 Background & aims: Physical inactivity and high energy intake contribute to the growing prevalence of overweight and obesity in pre-school children. Effective preventive interventions are warranted. In the present study the effect of a low threshold intervention on anthropometry and motor abilities of pre-school children was tested. Methods: A total of 1050 children from 27 kindergartens (16 intervention (n=688) and 11 control kindergartens (n=362)) were tested twice at a mean interval of five months (intervention group) respectively six months (control group). BMI and motor abilities were assessed. A standardised information meeting for parents and educators concerning test results, major evidence based key guidelines...
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Severe anal pain caused by food allergy?: A case report
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 10 April 2010
Veena, Zamvar , Ian D., Sugarman , John W.L., Puntis
 Introduction: Food allergy such as cow milk protein allergy (CMPA) is most common in early childhood, but may persist or develop in later life. Gastrointestinal symptoms are a common manifestation of food allergy but anal pain is highly unusual. Case presentation: We report the case of a ten-year-old boy who presented with severe anal pain that completely resolved on exclusion of cow milk from his diet. Conclusion: Severe anal pain is rare in children; this case suggests that once other pathology has been excluded a trial of dietary exclusion of common food allergens should be implemented.
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Effect of kale and papaya supplementation in colitis induced by trinitrobenzenesulfonic acid in the rat
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 7 April 2010
Cibele, Lima de Albuquerque , Monica, Comalada , Desiree, Camuesco , Maria Elena, RodrÃguez-Cabezas , Anderson, Luiz-Ferreira , ...
 Background & aims: Papaya and kale are usual vegetables in the Brazilian diet that have antioxidant activity. This study proposed to evaluate the effect of dried vegetables as a prebiotic and as an intestinal anti-inflammatory in the rat colitis model. Methods: Rats received, orally, 500mg/kg of rat weight of three treatments of dried vegetables: papaya, kale and the mixture of both vegetables (60% of kale plus 40% of papaya). In the prebiotic study, after two weeks of treatment, bacteria counts were determined. In the anti-inflammatory study, after the two weeks of treatment, colitis was induced by intracolonic administration of trinitrobenzenesulfonic acid (TNBS), and...
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Food choice is reflected in serum markers and anthropometric measures in healthy 8-yr-olds
Publication year: 2010
Source: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, In Press, Corrected Proof, Available online 17 March 2010
S., Eriksson , B., Strandvik
 Background: In healthy 4-yr-olds 17% were overweight/obese and high fat intake was associated with lower body weight and BMI. Aim: The objective was to analyse food intake and the relationship to anthropometry at the age of 8 yrs. Design: One-hundred and fourteen 8-yr-olds were investigated. Questionnaires were used for lifestyle, health and food choice combined with a 24-h dietary recall. Serum concentrations of vitamin D (25(OH)D) and phospholipid fatty acid concentrations were measured in 97 children. Results: Percentage of overweight/obesity was similar to 4-yr-olds. Saturated fat intake was higher than recommended. Consumption of full fat milk was negatively associated to BMI, like protein and fat intake per...
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