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Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 30 August 2010
Anna, Hsu , Richard S., Bruno , Christiane V., Löhr , Alan W., Taylor , Rodrick H., Dashwood , ...
Chronic inflammation and nuclear factor-kappa B (NFκB) have been implicated in prostate cancer development; thus, dietary factors that inhibit NFκB may serve as effective chemo-preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the United States, which has prompted interest in the potential chemopreventative action of Asian dietary components such as soy and green tea. This study examined the effects of dietary soy and tea on NFκB activation and inflammation in vivo using a hormone-induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy,...
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Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 30 August 2010
Giridhar, Kanuri , Astrid, Spruss , Sabine, Wagnerberger , Stephan C., Bischoff , Ina, Bergheim
Tumor necrosis factor α (TNFα) is known to be involved in dysregulation of hepatic lipid metabolism and insulin signaling. However, whether TNFα also plays a casual role in the onset of fructose-induced nonalcoholic fatty liver disease (NAFLD) has not yet been determined. Therefore, wild-type and TNFα receptor 1 (TNFR1)−/− mice were fed with either 30% fructose solution or plain tap water. Hepatic triglycerides, markers of inflammation and ATP concentration as well as plasma ALT levels were determined. Hepatic PAI-1, SREBP-1, FAS mRNA expression was assessed by real-time RT-PCR. Furthermore, lipid peroxidation and indices of insulin resistance were determined in liver...
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Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 30 August 2010
Mi-Ran, Ki , Hye-Rim, Lee , Jin-Kyu, Park , Il-Hwa, Hong , Seon-Young, Han , ...
The genetic deletion of the senescence marker protein 30 (SMP30) gene results in ascorbate deficiency and the premature aging processes in mice. Apparent liver injury of SMP30−/− mice was less severe than those of wild type (WT) mice, upon chronic CCl4 injection. The purpose of this study was to investigate the pathophysiology underlying the mild CCl4 toxicity in SMP30−/− mice. Along with the lower level of serum alanine aminotransferase, the livers of SMP30−/− mice revealed a lesser glycogen depletion, a decrease in c-Jun N-terminal kinase (JNK)-mediated inflammatory signaling in parallel with tumor necrosis factor-alpha and interleukin-1 beta, inducible nitric oxide...
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An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat☆☆☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 30 August 2010
Tomomi, Yamazaki , Sayaka, Shiraishi , Kyoko, Kishimoto , Shinji, Miura , Osamu, Ezaki
The effects of a diet rich in saturated fat on fatty liver formation and the related mechanisms that induce fatty liver were examined. C57BL/6J mice were fed butter or safflower oil as a high-fat (HF) diet (40% fat calories) for 2, 4, 10, or 17 weeks. Although both HF diets induced similar levels of obesity, HF butter-fed mice showed a two to threefold increase in liver triacylglycerol (TG) concentration compared to HF safflower oil-fed mice at 4 or 10 weeks without hyperinsulinemia. At 4 weeks, increases in peroxisome proliferator-activated receptor γ2 (PPARγ2), CD36, and adipose differentiation-related protein (ADRP) mRNAs were...
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Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 30 August 2010
Maria Esméria Corezola, do Amaral , Mirian, Ueno , Camila A.M., Oliveira , Natália C., Borsonello , Emerielle C., Vanzela , ...
Alterations in food intake such as caloric restriction modulate the expression of SIRT1 and SIRT4 proteins that are involved in pancreatic β-cell function. Here, we search for a possible relationship between insulin secretion and the expression of SIRT1, SIRT4, PKC and PKA in islets from adult rats submitted to CR for 21 days. Rats were fed with an isocaloric diet (CTL) or received 60% (CR) of the food ingested by CTL. The dose–response curve of insulin secretion to glucose was shifted to the right in the CR compared with CTL islets (EC50 of 15.1±0.17 and 10.5±0.11 mmol/L glucose). Insulin release...
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Table of Contents
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, Volume 21, Issue 9, September 2010, Page i
[No author name available]
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Novel histone biotinylation marks are enriched in repeat regions and participate in repression of transcriptionally competent genes☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 9 August 2010
Valerie, Pestinger , Subhashinee S.K., Wijeratne , Rocio, Rodriguez-Melendez , Janos, Zempleni
Covalent histone modifications play crucial roles in chromatin structure and genome stability. We previously reported biotinylation of lysine (K) residues in histones H2A, H3 and H4 by holocarboxylase synthetase and demonstrated that K12-biotinylated histone H4 (H4K12bio) is enriched in repeat regions and participates in gene repression. The biological functions of biotinylation marks other than H4K12bio are poorly understood. Here, novel biotinylation site-specific antibodies against H3K9bio, H3K18bio and H4K8bio were used in chromatin immunoprecipitation studies to obtain first insights into possible biological functions of these marks. Chromatin immunoprecipitation assays were conducted in human primary fibroblasts and Jurkat lymphoblastoma cells, and revealed...
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Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 5 August 2010
Ikumi, Iwashina , Kazuki, Mochizuki , Yuko, Inamochi , Toshinao, Goda
The expression of hexose transporter genes (SGLT1, GLUT5 and GLUT2) in mice with ad libitum feeding under light (7:00–19:00)–dark (19:00–7:00) cycle gradually increased from a basal level at 7:00 and reached a maximum at 19:00, coinciding with the start of dark phase feeding. The peaks of these gene expressions were shifted to 7:00 in mice that were subjected to a restricted feeding schedule from 9:00 to 17:00. The expression of BMAL1, a transcription factor driving the central feedback loop of the clock genes, was followed by the increase of hexose transporter gene expressions. The expressions of Per1-3, genes related to...
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Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 5 August 2010
Baolong, Bao , Valerie, Pestinger , Yousef I., Hassan , Gloria E.O., Borgstahl , Carol, Kolar , ...
Holocarboxylase synthetase (HCS) mediates the binding of biotin to lysine (K) residues in histones H2A, H3 and H4; HCS knockdown disturbs gene regulation and decreases stress resistance and lifespan in eukaryotes. We tested the hypothesis that HCS interacts physically with histone H3 for subsequent biotinylation. Co-immunoprecipitation experiments were conducted and provided evidence that HCS co-localizes with histone H3 in human cells; physical interactions between HCS and H3 were confirmed using limited proteolysis assays. Yeast two-hybrid (Y2H) studies revealed that the N-terminal and C-terminal domains in HCS participate in H3 binding. Recombinant human HCS was produced and exhibited biological activity, as...
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4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 5 August 2010
Yong Kyung, Lee , Im Seop, Choi , Jung Ok, Ban , Hwa Jeong, Lee , Ung Soo, Lee , ...
Oxidative stress induced neuronal cell death by accumulation of β-amyloid (Aβ) is a critical pathological mechanism of Alzheimer's disease (AD). Intracerebroventrical infusion of Aβ1-42 (300 pmol/day per mouse) for 14 days induced neuronal cell death and memory impairment, but pre-treatment of 4-O-methylhonokiol (4-O-MH), a novel compound extracted from Magnolia officinalis for 3 weeks (0.2, 0.5 and 1.0 mg/kg) prior to the infusion of Aβ1-42 and during the infusion dose dependently improved Aβ1-42-induced memory impairment and prevented neuronal cell death. Additionally, 4-O-MH reduced Aβ1-42 infusion-induced oxidative damages of protein and lipid but reduced glutathione levels in the cortex and hippocampus. Aβ1-42...
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Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort☆☆☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 5 August 2010
Dolores, Corella , Olga, Portolés , Larraitz, Arriola , MarÃa Dolores, Chirlaque , Aurelio, Barrricarte , ...
The association is still not clear between the common APOE polymorphism and coronary heart disease (CHD) risk, nor its modulation by diet. Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. We performed a nested case-control study in the Spanish European Prospective Investigation into Cancer and Nutrition cohort. Healthy men and women (41 440, 30–69 years) were followed up over a 10-year period, with the incident CHD cases being identified. We analyzed 534 incident CHD cases and 1123 controls. APOE, dietary intake and plasma lipids...
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Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 5 August 2010
Carolina, RamÃrez-Santana , Cristina, Castellote , Margarida, Castell , Carolina, Moltó-Puigmartà , Montserrat, Rivero , ...
Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respectively. The present study evaluates the influence of the same diet on antibody synthesis of early infant Wistar rats during suckling and/or after weaning. Dietary supplementation was performed during suckling and early infancy (4 weeks), only during suckling (3 weeks), or only in early infancy (1 week). CLA content in plasma and serum immunoglobulin (Ig) G, IgM and IgA concentration...
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Retinol inhibits aromatase activity and expression in vitro
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 4 August 2010
Henry P., Ciolino , Zhaoli, Dai , Vidhya, Nair
Aromatase converts androgens into estrogens and is thought to supply a local source of estrogen that facilitates the growth of hormone-responsive tumor cells. Inhibition of aromatase is therefore an important chemopreventive strategy. We investigated the effect of retinol and selected retinoids on the activity and expression of aromatase in two human carcinoma cell lines in vitro. Retinol (ROH) and all-trans retinoic acid (ATRA) significantly inhibited aromatase activity in a concentration-dependent manner in microsomes isolated from JEG-3 human placental carcinoma cells, whereas 9-cis and 13-cis retinoic acid had significant inhibitory activity only at the highest concentrations tested. Similar results were observed...
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Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 24 July 2010
Ganesh V., Halade , Md M., Rahman , Paul J., Williams , Gabriel, Fernandes
The inverse relationship between fat in bone marrow and bone mass in the skeleton of aging subjects is well known. However, there is no precise therapy for the treatment of bone marrow adiposity. We investigated the ability of conjugated linoleic acid (CLA) and fish oil (FO), alone or in combination, to modulate bone loss using 12 months old C57Bl/6J mice fed 10% corn oil diet as control or supplemented with 0.5% CLA or 5% FO or 0.5% CLA+5% FO for 6 months. We found, CLA-fed mice exhibited reduced body weight, body fat mass (BFM) and enhanced hind leg lean mass...
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High-fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 23 July 2010
Johan, De Vogel-van den Bosch , Sjoerd A.A., van den Berg , Silvia, Bijland , Peter J., Voshol , Louis M., Havekes , ...
Excess dietary long-chain fatty acid (LCFA) intake results in ectopic lipid accumulation and insulin resistance. Since medium-chain fatty acids (MCFA) are preferentially oxidized over LCFA, we hypothesized that diets rich in MCFA result in a lower ectopic lipid accumulation and insulin resistance compared to diets rich in LCFA. Feeding mice high-fat (HF) (45% kcal fat) diets for 8 weeks rich in triacylglycerols composed of MCFA (HFMCT) or LCFA (HFLCT) revealed a lower body weight gain in the HFMCT-fed mice. Indirect calorimetry revealed higher fat oxidation on HFMCT compared to HFLCT (0.011.0±0.0007 vs. 0.0096±0.0015 kcal/g body weight per hour, P<.05). In...
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Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 23 July 2010
Ximena, Terra , VÃctor, Pallarés , Anna, Ardèvol , Cinta, Bladé , Juan, Fernández-Larrea , ...
Chronic low-grade inflammation in obesity is characterized by macrophage accumulation in white adipose tissue (WAT) and abnormal cytokine production. We tested the hypothesis that grape-seed procyanidin extract (PE), with known anti-inflammatory and antioxidant effects, would improve local and systemic inflammation in diet-induced obesity rats. First, we analyzed the preventive effects of procyanidins (30 mg/kg per day) on rats fed a 60% kcal fat diet for 19 weeks. Second, we induced cafeteria diet obesity for 13 weeks to investigate the corrective effects of two PE doses (25 and 50 mg/kg per day) for 10 and 30 days.In the preventive model, PE...
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High lactation index is associated with insulin sensitivity☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 23 July 2010
Teresa H.M., Da Costa , Leslie J., Bluck
The aim of the study was to evaluate the contribution of lactation to insulin sensitivity in women 12 to 18 month postpartum using an oral glucose tolerance test (OGTT). Mean lactation index (LI), a scoring system that considers the establishment and maintenance of the lactation was used. Lactation index was calculated according to the number of months of breast-feeding per child with a maximum of 72 points. The mean LI was calculated by dividing the total number of points by the number of children. A cutoff point of 72 was considered for the LI. We investigated the inverse of the...
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Ginkgo biloba extract suppresses endotoxin-mediated monocyte activation by inhibiting nitric oxide- and tristetraprolin-mediated toll-like receptor 4 expression
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 23 July 2010
Yuan-Wen, Lee , Jui-An, Lin , Chuen-Chau, Chang , Yung-Hsiang, Chen , Po-Len, Liu , ...
Monocytes expressing toll-like receptor 4 (TLR4) play a major role in regulating the innate immune response and are involved in systemic inflammation. Previous studies have shown that Ginkgo biloba extract (GBE) may act as a therapeutic agent for some cardiovascular and neurological disorders. The objective of this study was to determine whether GBE could modulate immunity in human cells. The monocytic cell line THP-1 was used. Enzyme-linked immunosorbent assay results showed that lipopolysaccharide (LPS) induces the expression of monocyte chemotactic protein-1 (MIP-1), tumor necrosis factor-α, stromal cell-derived factor-1, and MIP-1α, and this induction may be repressed by GBE treatment due...
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Cox-2 expression, PGE2 and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 23 July 2010
Claudia, Gravaghi , Krista M.D., La Perle , Paul, Ogrodwski , Jing X., Kang , Fred, Quimby , ...
There is great interest in the role of polyunsaturated fatty acids (PUFAs) in promoting (n-6 class) or inhibiting (n-3 class) inflammation. Mammalian cells are devoid of desaturase that converts n-6 to n-3 PUFAs. Consequently, essential n-3 fatty acids must be supplied with the diet. We have studied the effect of endogenously produced n-3 PUFAs on colitis development in fat-1 transgenic mice carrying the Caenorhabditis elegans fat-1 gene encoding n-3 desaturase. Colonic cell lipid profile was measured by capillary gas chromatography in fat-1 and wild-type (WT) littermates fed standard diet supplemented with 10% (w/w) safflower oil rich (76%) in n-6 polyunsaturated...
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Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice☆
Publication year: 2010
Source: The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 23 July 2010
Hea Jin, Park , Dana A., DiNatale , Min-Yu, Chung , Young-Ki, Park , Ji-Young, Lee , ...
Excess hepatic lipid accumulation and oxidative stress contribute to nonalcoholic fatty liver disease (NAFLD). Thus, we hypothesized that the hypolipidemic and antioxidant activities of green tea extract (GTE) would attenuate events leading to NAFLD. Obese mice (ob/ob; 5 weeks old, n=38) and their lean littermates (n=12) were fed 0%, 0.5% or 1% GTE for 6 weeks. Then, hepatic steatosis, oxidative stress and inflammatory markers were measured. Obese mice, compared to lean controls, had greater hepatic lipids and serum alanine aminotransferase (ALT). GTE at 1% lowered (P<.05) hepatic lipids and ALT in obese mice. The GTE-mediated attenuation in hepatic steatosis was...
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